Hyper-inflammatory Disease in the Weimaraner

Hypertrophic osteodystrophy (HOD) is a major manifestation of the hyper-inflammatory syndrome, and causes high fever, pain and lameness associated with swelling of the growth plates in the femur and humerus. This is typically seen in one or two puppies in a genetically susceptible litter, soon after they receive multivalent vaccination, although it also can occur after monovalent vaccination. Other recognized disease syndromes include a post-vaccinal reaction with high fever and nodular skin disease; humoral antibody immunodeficiency syndrome with recurrent infections involving the bowel, skin, and urinary tract; and aseptic meningitis.